role of vitamin k in blood clotting ppt

1 0 obj Vitamin K. This vitamin is the most important of all the fat soluble vitamins. Vitamin K plays a key role in blood clotting. <>>> The most important function of this vitamin in our body is to clot blood. Liver disease and vitamin K deficiency lead to a marked decrease in the synthesis of prothrombin (factor II) and factors VII, IX, and X. Vitamin K doesn't really cause blood clotting, but it plays a key role in the formation of clots. It is also useful in correcting hypoprothrombinemia of the newborn. Hemostasis includes three steps that occur in a rapid sequence: (1) vascular spasm, or vasoconstriction, a brief and intense contraction of blood vessels; (2) formation of a platelet plug; and (3) blood clotting or coagulation, which reinforces the platelet plug with fibrin mesh that acts as a … i��Xp��P�,:pb2.��R������_���q�lS����A�Sl�漎�]�5����D�x��d( Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. %PDF-1.5 o Warfarin is a synthetic analogue that can inhibit vitamin K action o Role of Gla in clotting: o γ - Carboxyglutamic acid (Gla) residues of clotting factors are negatively charged (COO-) and they combine with Positively charged calcium ions (Ca2+) to form a complex o The complex binds to the phospholipids on the membrane surface of the platelets o Leads to increased conversion of … Blood Clotting Disorder | Hematologist in Pune - When a cut or injury occurs, the body stops the bleeding by forming a blood clot. A lack of factor IX is the basis for hemophilia B. Synthesis is vitamin K–dependent. Vitamin K helps to regulate the process of blood coagulation by assisting in the conversion certain coagulation factors into their mature forms. There are several forms K1-K7; 59 Vitamin K1 (Phylloquinone) Naturally occurring vitamin K is absorbed from Vitamin K1 Promotes Blood Clotting. Although the coagulant factors are the most well-known VKDPs, there are many others with important physiologic roles. Role of vitamin K in coagulation Gamma carboxylation imparts another negative charge to promote the effective binding of these factors/proteins to calcium ions. The functions of vitamin K are concerned with blood clotting process. Also known as Coumadin by its brand name. They are synthesised by the bacteria in our gut/throat. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. XI: Plasma thromboplastin antecedent It was established that vitamin K activated certain proteins that are required for normal blood clotting. <> Vitamin k is of greatest value in correcting the abnormal blood coagulation due to hypoprothrombinemia as a result of obstructive jaundice or biliary fistulas. It is aptly named since vitamin K is a necessary component for blood clotting. Vitamin K Vitamin K is a cofactor needed for the synthesis (in the liver) of factors 2 (prothrombin), 7, 9, and 10; proteins C and S. So a deficiency of Vitamin K predisposes to bleeding. γ-Carboxyglutamates by chelating calcium ions, therefore, permit the binding of the blood clotting proteins to membranes. It has a key role to play in blood clotting and is also essential to maintain homeostasis. 2 0 obj endobj Note: Vitamin K is responsible for making blood clotting factors and prevents excessive bleeding. 4. blood-clotting factors! Vitamin K oc… Prothrombin is transformed into thrombin by a clotting factor known as factor X or prothrombinase; thrombin then acts to transform fibrinogen, also present Vitamin K-dependent proteins (VKDPs) require carboxylation to become biologically active. endobj When a diet is deficient in vitamin K storage forms are transported by VLDL, LDL, and HDL. �@Q�挕��� %����Q' Protein structure, Protein unfolding and misfolding. Upon injury to a blood vessel, platelets stick to the wound forming a plug. Involved in synthesizing . Subscripts added for each new isolated role. �5�t��NtM�!�� Vitamin K: Functions in Blood. Did you ever wonder what the \"K\" stands for in vitamin K? Clipping is a handy way to collect important slides you want to go back to later. Prothrombin and several other proteins of the blood clotting system (Factors VII, IX, and X, and … Conversely, blocking the action of vitamin K helps to prevent inappropriate clotting. /�P�nqM����V%��!ڑSШ�P��N�l���O?s��;�b�ڐ� �M.S��a�T�S��Q�dB�B���) ��� J,��*|,��:�� �r���f�tq�>��N:�5�����j�lM3Ϋ��ڌ��Ts�մ#� �5 Blood-clotting proteins are continuously circulating in the blood. Whenever your skin becomes broken, the sticky platelets contained in the blood form clots to stop blood flow. �CH��SLVԫg�r���ӓ���, Without vitamin K , … One of the factors implicated in the pathogenesis of the coagulopathy of liver disease is vitamin K deficiency. Synthetic vitamin k products, generally more potent than the natural vitamin, are naphthoquinone derivatives, most of which are water-soluble and can be administered parenterally. Vitamin K dependent proteins have been identified in bone, kidney and other tissues. Vitamin K act as a Coenzyme for the carboxylation of ���@�i+W��(��;"���*z]�y�tӔ 3$�1�1~�d�c��#LH,�T^(��Nb�Յ�H'�"AČ�%.vp��! It takes the shape of scab and protects the wound from spreading and stops the bleeding. It is also useful in correcting hypoprothrombinemia of the newborn. Synthesis is vitamin K–dependent. Manganese is absorbed in the small intestine through an active transport system and, possibly, through diffusion when intakes are high .

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